In this day and age, we are all [mostly] fully aware how far signature-based antivirus detections go... not very far at all in regard to real-time protection. Users will get infected, there are no longer any IF statements in this equation. My focus is the gray area of post-infection and the many different aspects of end-user and incident response frustration that occur after a virus has penetrated a system, or organization, and done its dirty work. I will also be going over various malware removal and mitigation techniques, tools of the trade, and general guidelines to follow to prevent infections from happening in the first place.