Lately, many popular anti-virus solutions claim to be the most effective against unknown and obfuscated malware. Most of these solutions are rather vague about how they supposedly achieve this goal, making it hard for end-users to evaluate and compare the effectiveness of the different products on the market. This presentation presents empirically discovered results on the various implementations of these methods per solution, which reveal that some anti-virus solutions have more mature methods to detect x86 malware than others, but all of them are lagging behind when it comes to x64 malware. In general, at most three stages were identified in the detection process: Static detection, Code Emulation detection (before execution), and Runtime detection (during execution). New generic evasion techniques are presented for each of these stages. These techniques were implemented by an advanced, dedicated packer, which is an approach commonly taken by malware developers to evade detection of their malicious toolset. Two brand new packing methods were developed for this cause. By combining several evasion techniques, real-world malicious executables with a high detection rate were rendered completely undetected to the prying eyes of anti-virus products.